diff --git a/cmd/evm/internal/t8ntool/transaction.go b/cmd/evm/internal/t8ntool/transaction.go
index bc9bc42edc..576d1db84b 100644
--- a/cmd/evm/internal/t8ntool/transaction.go
+++ b/cmd/evm/internal/t8ntool/transaction.go
@@ -154,6 +154,8 @@ func Transaction(ctx *cli.Context) error {
 		}
 		// Validate <256bit fields
 		switch {
+		case tx.Nonce()+1 < tx.Nonce():
+			r.Error = errors.New("nonce exceeds 2^64-1")
 		case tx.Value().BitLen() > 256:
 			r.Error = errors.New("value exceeds 256 bits")
 		case tx.GasPrice().BitLen() > 256:
diff --git a/core/error.go b/core/error.go
index 594f3a26e5..51ebefc137 100644
--- a/core/error.go
+++ b/core/error.go
@@ -51,6 +51,10 @@ var (
 	// next one expected based on the local chain.
 	ErrNonceTooHigh = errors.New("nonce too high")
 
+	// ErrNonceMax is returned if the nonce of a transaction sender account has
+	// maximum allowed value and would become invalid if incremented.
+	ErrNonceMax = errors.New("nonce has max value")
+
 	// ErrGasLimitReached is returned by the gas pool if the amount of gas required
 	// by a transaction is higher than what's left in the block.
 	ErrGasLimitReached = errors.New("gas limit reached")
diff --git a/core/state_processor_test.go b/core/state_processor_test.go
index 13a9eb810d..aa8e4bebf9 100644
--- a/core/state_processor_test.go
+++ b/core/state_processor_test.go
@@ -17,10 +17,12 @@
 package core
 
 import (
+	"crypto/ecdsa"
 	"math/big"
 	"testing"
 
 	"github.com/ethereum/go-ethereum/common"
+	"github.com/ethereum/go-ethereum/common/math"
 	"github.com/ethereum/go-ethereum/consensus"
 	"github.com/ethereum/go-ethereum/consensus/ethash"
 	"github.com/ethereum/go-ethereum/consensus/misc"
@@ -54,11 +56,12 @@ func TestStateProcessorErrors(t *testing.T) {
 			LondonBlock:         big.NewInt(0),
 			Ethash:              new(params.EthashConfig),
 		}
-		signer     = types.LatestSigner(config)
-		testKey, _ = crypto.HexToECDSA("b71c71a67e1177ad4e901695e1b4b9ee17ae16c6668d313eac2f96dbcda3f291")
+		signer  = types.LatestSigner(config)
+		key1, _ = crypto.HexToECDSA("b71c71a67e1177ad4e901695e1b4b9ee17ae16c6668d313eac2f96dbcda3f291")
+		key2, _ = crypto.HexToECDSA("0202020202020202020202020202020202020202020202020202002020202020")
 	)
-	var makeTx = func(nonce uint64, to common.Address, amount *big.Int, gasLimit uint64, gasPrice *big.Int, data []byte) *types.Transaction {
-		tx, _ := types.SignTx(types.NewTransaction(nonce, to, amount, gasLimit, gasPrice, data), signer, testKey)
+	var makeTx = func(key *ecdsa.PrivateKey, nonce uint64, to common.Address, amount *big.Int, gasLimit uint64, gasPrice *big.Int, data []byte) *types.Transaction {
+		tx, _ := types.SignTx(types.NewTransaction(nonce, to, amount, gasLimit, gasPrice, data), signer, key)
 		return tx
 	}
 	var mkDynamicTx = func(nonce uint64, to common.Address, gasLimit uint64, gasTipCap, gasFeeCap *big.Int) *types.Transaction {
@@ -69,7 +72,7 @@ func TestStateProcessorErrors(t *testing.T) {
 			Gas:       gasLimit,
 			To:        &to,
 			Value:     big.NewInt(0),
-		}), signer, testKey)
+		}), signer, key1)
 		return tx
 	}
 	{ // Tests against a 'recent' chain definition
@@ -82,6 +85,10 @@ func TestStateProcessorErrors(t *testing.T) {
 						Balance: big.NewInt(1000000000000000000), // 1 ether
 						Nonce:   0,
 					},
+					common.HexToAddress("0xfd0810DD14796680f72adf1a371963d0745BCc64"): GenesisAccount{
+						Balance: big.NewInt(1000000000000000000), // 1 ether
+						Nonce:   math.MaxUint64,
+					},
 				},
 			}
 			genesis       = gspec.MustCommit(db)
@@ -97,32 +104,38 @@ func TestStateProcessorErrors(t *testing.T) {
 		}{
 			{ // ErrNonceTooLow
 				txs: []*types.Transaction{
-					makeTx(0, common.Address{}, big.NewInt(0), params.TxGas, big.NewInt(875000000), nil),
-					makeTx(0, common.Address{}, big.NewInt(0), params.TxGas, big.NewInt(875000000), nil),
+					makeTx(key1, 0, common.Address{}, big.NewInt(0), params.TxGas, big.NewInt(875000000), nil),
+					makeTx(key1, 0, common.Address{}, big.NewInt(0), params.TxGas, big.NewInt(875000000), nil),
 				},
 				want: "could not apply tx 1 [0x0026256b3939ed97e2c4a6f3fce8ecf83bdcfa6d507c47838c308a1fb0436f62]: nonce too low: address 0x71562b71999873DB5b286dF957af199Ec94617F7, tx: 0 state: 1",
 			},
 			{ // ErrNonceTooHigh
 				txs: []*types.Transaction{
-					makeTx(100, common.Address{}, big.NewInt(0), params.TxGas, big.NewInt(875000000), nil),
+					makeTx(key1, 100, common.Address{}, big.NewInt(0), params.TxGas, big.NewInt(875000000), nil),
 				},
 				want: "could not apply tx 0 [0xdebad714ca7f363bd0d8121c4518ad48fa469ca81b0a081be3d10c17460f751b]: nonce too high: address 0x71562b71999873DB5b286dF957af199Ec94617F7, tx: 100 state: 0",
 			},
+			{ // ErrNonceMax
+				txs: []*types.Transaction{
+					makeTx(key2, math.MaxUint64, common.Address{}, big.NewInt(0), params.TxGas, big.NewInt(875000000), nil),
+				},
+				want: "could not apply tx 0 [0x84ea18d60eb2bb3b040e3add0eb72f757727122cc257dd858c67cb6591a85986]: nonce has max value: address 0xfd0810DD14796680f72adf1a371963d0745BCc64, nonce: 18446744073709551615",
+			},
 			{ // ErrGasLimitReached
 				txs: []*types.Transaction{
-					makeTx(0, common.Address{}, big.NewInt(0), 21000000, big.NewInt(875000000), nil),
+					makeTx(key1, 0, common.Address{}, big.NewInt(0), 21000000, big.NewInt(875000000), nil),
 				},
 				want: "could not apply tx 0 [0xbd49d8dadfd47fb846986695f7d4da3f7b2c48c8da82dbc211a26eb124883de9]: gas limit reached",
 			},
 			{ // ErrInsufficientFundsForTransfer
 				txs: []*types.Transaction{
-					makeTx(0, common.Address{}, big.NewInt(1000000000000000000), params.TxGas, big.NewInt(875000000), nil),
+					makeTx(key1, 0, common.Address{}, big.NewInt(1000000000000000000), params.TxGas, big.NewInt(875000000), nil),
 				},
 				want: "could not apply tx 0 [0x98c796b470f7fcab40aaef5c965a602b0238e1034cce6fb73823042dd0638d74]: insufficient funds for gas * price + value: address 0x71562b71999873DB5b286dF957af199Ec94617F7 have 1000000000000000000 want 1000018375000000000",
 			},
 			{ // ErrInsufficientFunds
 				txs: []*types.Transaction{
-					makeTx(0, common.Address{}, big.NewInt(0), params.TxGas, big.NewInt(900000000000000000), nil),
+					makeTx(key1, 0, common.Address{}, big.NewInt(0), params.TxGas, big.NewInt(900000000000000000), nil),
 				},
 				want: "could not apply tx 0 [0x4a69690c4b0cd85e64d0d9ea06302455b01e10a83db964d60281739752003440]: insufficient funds for gas * price + value: address 0x71562b71999873DB5b286dF957af199Ec94617F7 have 1000000000000000000 want 18900000000000000000000",
 			},
@@ -132,13 +145,13 @@ func TestStateProcessorErrors(t *testing.T) {
 			// multiplication len(data) +gas_per_byte overflows uint64. Not testable at the moment
 			{ // ErrIntrinsicGas
 				txs: []*types.Transaction{
-					makeTx(0, common.Address{}, big.NewInt(0), params.TxGas-1000, big.NewInt(875000000), nil),
+					makeTx(key1, 0, common.Address{}, big.NewInt(0), params.TxGas-1000, big.NewInt(875000000), nil),
 				},
 				want: "could not apply tx 0 [0xcf3b049a0b516cb4f9274b3e2a264359e2ba53b2fb64b7bda2c634d5c9d01fca]: intrinsic gas too low: have 20000, want 21000",
 			},
 			{ // ErrGasLimitReached
 				txs: []*types.Transaction{
-					makeTx(0, common.Address{}, big.NewInt(0), params.TxGas*1000, big.NewInt(875000000), nil),
+					makeTx(key1, 0, common.Address{}, big.NewInt(0), params.TxGas*1000, big.NewInt(875000000), nil),
 				},
 				want: "could not apply tx 0 [0xbd49d8dadfd47fb846986695f7d4da3f7b2c48c8da82dbc211a26eb124883de9]: gas limit reached",
 			},
diff --git a/core/state_transition.go b/core/state_transition.go
index 6a09f6adc4..135a9c6dbe 100644
--- a/core/state_transition.go
+++ b/core/state_transition.go
@@ -222,6 +222,9 @@ func (st *StateTransition) preCheck() error {
 		} else if stNonce > msgNonce {
 			return fmt.Errorf("%w: address %v, tx: %d state: %d", ErrNonceTooLow,
 				st.msg.From().Hex(), msgNonce, stNonce)
+		} else if stNonce+1 < stNonce {
+			return fmt.Errorf("%w: address %v, nonce: %d", ErrNonceMax,
+				st.msg.From().Hex(), stNonce)
 		}
 		// Make sure the sender is an EOA
 		if codeHash := st.state.GetCodeHash(st.msg.From()); codeHash != emptyCodeHash && codeHash != (common.Hash{}) {
diff --git a/core/vm/errors.go b/core/vm/errors.go
index c7cfeae53c..565eecdd7c 100644
--- a/core/vm/errors.go
+++ b/core/vm/errors.go
@@ -35,6 +35,7 @@ var (
 	ErrReturnDataOutOfBounds    = errors.New("return data out of bounds")
 	ErrGasUintOverflow          = errors.New("gas uint64 overflow")
 	ErrInvalidCode              = errors.New("invalid code: must not begin with 0xef")
+	ErrNonceUintOverflow        = errors.New("nonce uint64 overflow")
 )
 
 // ErrStackUnderflow wraps an evm error when the items on the stack less
diff --git a/core/vm/evm.go b/core/vm/evm.go
index 07e9619158..618bbcf176 100644
--- a/core/vm/evm.go
+++ b/core/vm/evm.go
@@ -424,6 +424,9 @@ func (evm *EVM) create(caller ContractRef, codeAndHash *codeAndHash, gas uint64,
 		return nil, common.Address{}, gas, ErrInsufficientBalance
 	}
 	nonce := evm.StateDB.GetNonce(caller.Address())
+	if nonce+1 < nonce {
+		return nil, common.Address{}, gas, ErrNonceUintOverflow
+	}
 	evm.StateDB.SetNonce(caller.Address(), nonce+1)
 	// We add this to the access list _before_ taking a snapshot. Even if the creation fails,
 	// the access-list change should not be rolled back